Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms

Table 3 Hematological, biochemical, and inflammatory parameters in patients and controls (n = 180), mean ± SD

Parameter	Patients (n = 90)	Controls (n = 90)	P value
Hematological parameters
Hemoglobin (g/dL)	8.31 ± 1.03	13.41 ± 0.77	< 0.001c
Platelet count (× 109/L)	95.4 ± 9.87	258.3 ± 60.98	< 0.001c
Total leukocyte count (× 109/L)	20.74 ± 21.78	7.43 ± 1.81	0.209
Neutrophil count (× 109/L)	3.1 ± 2.79	4.16 ± 1.05	0.005b
Lymphocyte count (× 109/L)	15.99 ± 17.73	2.36 ± 0.73	0.010a
Monocyte count (× 109/L)	0.591 ± 0.233	0.500 ± 0.150	0.774
Eosinophil count (× 109/L)	0.244 ± 0.259	0.268 ± 0.165	0.008b
Biochemical parameters
LDH (U/L)	615.9 ± 69.72	121.6 ± 18.05	< 0.001c
CRP (mg/L)	28.2 ± 12.22	3.43 ± 1.61	< 0.001c
Ferritin (ng/mL)	540 ± 84.64	82.2 ± 40.81	< 0.001c
Transferrin saturation (%)	36.87 ± 7.3	64.67 ± 16.13	< 0.001c
Beta-2 microglobulin (mg/L)	3.8 ± 1.2	1.8 ± 0.5	< 0.001c
Albumin (g/dL)	3.5 ± 0.6	4.3 ± 0.4	< 0.001c
ESR (mm/hour)	45.0 ± 15.0	12.0 ± 4.0	< 0.001c
Inflammatory indices
SII	30971.8 ± 14428.6	455.0 ± 211.9	< 0.001c
SIRI	250.7 ± 200.2	1.1 ± 0.5	< 0.001c
Platelet-to-lymphocyte ratio	29.6 ± 23.97	115.0 ± 38.33	< 0.001c
Neutrophil-to-lymphocyte ratio	0.32 ± 0.14	1.68 ± 0.58	< 0.001c
Ferritin-to-lymphocyte ratio	0.18 ± 0.17	0.04 ± 0.02	0.016a
White cell-to-lymphocyte ratio	1.44 ± 0.15	3.25 ± 0.62	< 0.001c
LDH-to-lymphocyte ratio	26.37 ± 27.93	21.14 ± 9.28	0.133

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

LDH: Lactate dehydrogenase; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index.