Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms

doi:10.5306/wjco.v17.i1.112801

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jan 24, 2026; 17(1): 112801
Published online Jan 24, 2026. doi: 10.5306/wjco.v17.i1.112801

Table 14 Subtype-stratified receiver operating characteristic analysis for stage IV lymphoma

Biomarker	Subtype	AUC (95%CI)	P value
PD-1/CXCR3	DLBCL	0.970 (0.910-1.000)	< 0.001^b
PD-1/CXCR3	CLL	0.950 (0.880-1.000)	< 0.001^b
SIRI	DLBCL	0.820 (0.700-0.940)	0.008^a
SIRI	CLL	0.880 (0.780-0.980)	0.002^a

^aP < 0.01.

^bP < 0.001.

PD-L1: Programmed death-ligand 1; CXCR3: C-X-C motif chemokine receptor 3; SIRI: Systemic inflammation response index; AUC: Area under the curve; CI: Confidence interval; DLBCL: Diffuse large B-cell lymphoma; CLL: Chronic lymphocytic leukemia.

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Citation: Sherief DE, Nosair N, Abdelhameed AM, Sadaka E, Othman AAA, Elgamal R. Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms. World J Clin Oncol 2026; 17(1): 112801
URL: https://www.wjgnet.com/2218-4333/full/v17/i1/112801.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i1.112801

Sherief DE, Nosair N, Abdelhameed AM, Sadaka E, Othman AAA, Elgamal R. Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms. World J Clin Oncol 2026; 17(1): 112801 [PMID: 41608342 DOI: 10.5306/wjco.v17.i1.112801]

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