Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms

Table 12 Multivariate Cox regression for overall survival and event-free survival (n = 90)

Parameter	OS HR (95%CI)	OS (P value)	EFS HR (95%CI)	EFS (P value)
SII (high vs low)	1.20 (0.70-2.05)	0.510	1.85 (1.10-3.12)	0.021a
SIRI (high vs low)	0.45 (0.22-0.91)	0.026a	1.50 (0.90-2.50)	0.120
PD-L1/CXCR3 (high vs low)	2.15 (1.23-3.76)	0.007b	2.50 (1.45-4.31)	0.001b
PD-1/CXCR3 (high vs low)	1.98 (1.12-3.50)	0.019a	2.20 (1.28-3.78)	0.004b
CXCR3/T-lymphocytes (high vs low)	2.30 (1.30-4.07)	0.004b	2.00 (1.15-3.48)	0.014b

^aP < 0.05.

^bP < 0.01.

SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index; PD-L1: Programmed death-ligand 1; CXCR3: C-X-C motif chemokine receptor 3; PD-1: Programmed cell death protein 1; OS: Overall survival; HR: Hazard ratio; EFS: Event-free survival.