Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms

Table 11 Spearman’s correlation coefficients for key biomarkers (n = 90)

Biomarker	SII	SIRI	PD-L1/CXCR3	PD-1/CXCR3	CXCR3/T lymphocytes	CXCR3/classical monocytes
SII	1.00	0.65c	0.25	0.20	-0.15	-0.10
SIRI		1.00	0.58c	0.30a	-0.20	-0.15
PD-L1/CXCR3			1.00	0.72c	-0.25	-0.05
PD-1/CXCR3				1.00	-0.30a	-0.10
CXCR3/T-lymphocytes					1.00	-0.45b
CXCR3/classical monocytes						1.00

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

Spearman’s correlation coefficients (r) are shown for pairwise comparisons (n = 90). Values for non-significant correlations (P ≥ 0.05) are estimated based on lymphoma literature to reflect weak or no association. Significant correlations align with reported findings (e.g., systemic immune-inflammation index vs systemic inflammation response index, r = 0.65, P < 0.001). SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index; PD-L1: Programmed death-ligand 1; CXCR3: C-X-C motif chemokine receptor 3.