Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms

doi:10.5306/wjco.v17.i1.112801

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jan 24, 2026; 17(1): 112801
Published online Jan 24, 2026. doi: 10.5306/wjco.v17.i1.112801

Table 10 Kaplan-Meier survival curve for event-free survival with different parameters (n = 90), mean ± SD

Parameter	Group (n)	Mean EFS (months)	Survival at endpoint (%)	Log-rank χ²	P value	Hazard ratio (95%CI)
SII	Low (45)	24.19 ± 1.80	60.0	8.857	0.003^b	1.75 (1.15-2.65)
SII	High (45)	18.65 ± 2.50	30.0	8.857	0.003^b	1.75 (1.15-2.65)
SIRI	Low (45)	22.44 ± 2.00	60.0	4.625	0.032^a	1.50 (1.00-2.25)
SIRI	High (45)	19.06 ± 2.30	30.0	4.625	0.032^a	1.50 (1.00-2.25)
PD-L1/CXCR3	Low (45)	27.857 ± 1.50	70.0	15.498	< 0.001^c	2.00 (1.30-3.00)
PD-L1/CXCR3	High (45)	18.005 ± 2.00	30.0	15.498	< 0.001^c	2.00 (1.30-3.00)
PD-1/CXCR3	Low (45)	24.067 ± 1.50	80.0	23.331	< 0.001^c	2.20 (1.40-3.40)
PD-1/CXCR3	High (45)	17.648 ± 2.20	30.0	23.331	< 0.001^c	2.20 (1.40-3.40)
CXCR3/T lymphocytes (%)	Low (45)	24.354 ± 1.50	60.0	8.987	0.003^b	1.80 (1.20-2.70)
CXCR3/T lymphocytes (%)	High (45)	18.700 ± 2.00	30.0	8.987	0.003^b	1.80 (1.20-2.70)
CXCR3/classical monocytes (%)	Low (45)	21.727 ± 1.80	40.0	1.532	0.216	1.20 (0.80-1.80)
CXCR3/classical monocytes (%)	High (45)	19.462 ± 2.00	40.0	1.532	0.216	1.20 (0.80-1.80)
CXCR3/intermediate monocytes (%)	Low (45)	22.525 ± 1.80	40.0	3.561	0.059	1.30 (0.85-2.00)
CXCR3/intermediate monocytes (%)	High (45)	18.531 ± 2.00	40.0	3.561	0.059	1.30 (0.85-2.00)
CXCR3/non-classical monocytes (%)	Low (45)	22.072 ± 1.90	40.0	1.874	0.171	1.20 (0.80-1.80)
CXCR3/non-classical monocytes (%)	High (45)	19.087 ± 2.00	40.0	1.874	0.171	1.20 (0.80-1.80)

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index; PD-L1: Programmed death-ligand 1; CXCR3: C-X-C motif chemokine receptor 3; PD-1: Programmed cell death protein 1; EFS: Event-free survival; CI: Confidence interval.

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Citation: Sherief DE, Nosair N, Abdelhameed AM, Sadaka E, Othman AAA, Elgamal R. Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms. World J Clin Oncol 2026; 17(1): 112801
URL: https://www.wjgnet.com/2218-4333/full/v17/i1/112801.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i1.112801

Sherief DE, Nosair N, Abdelhameed AM, Sadaka E, Othman AAA, Elgamal R. Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms. World J Clin Oncol 2026; 17(1): 112801 [PMID: 41608342 DOI: 10.5306/wjco.v17.i1.112801]

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