Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms

Figure 4 Immunohistochemical evaluation of murine double minute 2 nuclear expression in bone marrow samples of patients with multiple myeloma. Immunohistochemical analysis illustrating murine double minute 2 (MDM2) expression obtained from extramedullary lesions of patients diagnosed with multiple myeloma. Detection was performed using the DAB chromogen, with positively stained nuclei exhibiting a characteristic brown hue. The intensity and extent of nuclear MDM2 expression varied among cases. A-C: Images depict mild to focal nuclear MDM2 staining confined to scattered malignant plasma cells; D-F: Fields demonstrate a higher frequency and intensity of nuclear MDM2 expression, with numerous plasma cells exhibiting moderate to strong positivity. Original magnification: A-D (× 200), E and F (× 400).