Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms

Figure 2 Peripheral blood smears from a patient diagnosed with multiple myeloma with plasma cell leukemia exhibit distinct morphological hallmarks. A prominent feature is the presence of rouleaux formation, where red blood cells appear stacked, typically reflecting elevated serum protein levels. Notably, several abnormal plasma cells are observed, characterized by eccentrically positioned nuclei, deeply basophilic cytoplasm, and a perinuclear clearing (Hof). Staining technique: Wright-Giemsa. Magnification: 1000 × under oil immersion. These hematologic findings are consistent with multiple myeloma and align with the presence of circulating malignant plasma cells and blood hyperviscosity commonly seen in advanced stages of the disease.