MiR-451a targets mex-3 RNA binding family member C to regulate human hepatoblastoma G2 cell growth and metastasis

Figure 1 MiR-451a expression in liver cancer tissues and construction of miR-451a stable up-expression cell lines. A: MiR-451a expression down-regulated in liver cancer tissues; B: Human hepatoblastoma G2 (HepG2) cells transfect with lentivirus-negative control (LV-NC) virus and lentivirus miR-451a (LV-miR-451a) virus, respectively (magnification 100 ×). Figures from left to right are HepG2 cells under bright field, green fluorescence produced by the expressed green fluorescence protein (GFP) fused with the GV369 vector; C: BEL-7404 cells transfect with LV-NC virus and LV-miR-451a virus, respectively (magnification 100 ×). Figures from left to right are BEL-7404 cells under bright field, green fluorescence produced by the expressed GFP fused with the GV369 vector; D: Quantitative real-time quantitative polymerase chain reaction result showed that miR-451a significantly up-regulated in HepG2 and BEL-7404 cells after transfecting with LV-miR-451a virus compared with LV-NC group (^aP < 0.05). HCC: Hepatocellular carcinoma; HepG2: Human hepatoblastoma G2; LV-miR-451a: Lentivirus miR-451a; LV-NC: Lentivirus-negative control.