Historical rise of cancer and dietary linoleic acid: Mechanisms and therapeutic strategies

Table 1 Twentieth-century surge in dietary and adipose linoleic acid with parallel rise in United States cancer incidence

Decade	Per-capita linoleic acid intake (% kcal)	Adipose-tissue linoleic acid (% fatty acid)	Age-adjusted total cancer incidence (per 100000)	Key dietary milestone
1900s	1-2	N/A	Approximately 90	Minimal seed-oil use
1950s	3-4	Approximately 8%	Approximately 180	Margarine adoption
1980s	6-7	Approximately 14%	Approximately 310	Widespread soybean oil
2000s	7-8	Approximately 18%	Approximately 460	Ultra-processed foods

N/A: Not applicable.