Lynch syndrome association and clinicopathological features in early-onset colorectal cancers: A single-center retrospective study

Table 2 Clinicopathological comparisons between the two groups based on microsatellite status determined by immunohistochemistry results, n (%)

Descriptive and clinical features	Microsatellite instabil	Microsatellite stabile	P value
Age group, median (IQR)	42 (7)	46 (10)	0.0351
21-30	0 (0)	5 (5)
31-40	14 (46.7)	29 (29)
41-50	16 (53.3)	66 (66)
Sex
Male	21 (70)	48 (48)	0.0342
Female	9 (30)	52 (52)
Survey (month), median (IQR)	52 (42.5)	38 (45)	0.0201
Right colon and transvers colon
Negative	10 (31.2)	71 (69.6)	< 0.0012
Positive	22 (68.7)	31 (30.3)
Rectosigmoid colon and rectum
Negative	29 (90.6)	69 (67.6)	0.0112
Positive	3 (9.3)	33 (29.4)
Musinous component in the tumor
Negative	15 (50)	77 (77)	0.0042
Positive	15 (50)	23 (23)
LN metastasis
Negative	22 (73.3)	51 (51)	0.0312
Positive	8 (26.7)	49 (49)
Number of positive LNs, median (IQR)	0 (1)	0 (3)	0.0311
T stage			-
T1	0 (0)	1 (1)
T2	2 (6.7)	7 (7)
T3	21 (70)	60 (60)
T4a ve T4b	7 (23.3)	32 (32)
N stage			-
N0	21 (70)	42 (42)
N1a, N1b ve N1c	6 (20)	34 (34)
N2a ve N2b	3 (10)	24 (24)
Metastasis
Negative	28 (93.3)	70 (70)	0.0092
Positive	2 (6.7)	30 (30)
Stage			0.0122
1	2 (6.7)	6 (6)
2	18 (60)	30 (30)
3	8 (26.7)	35 (35)
4	2 (6.7)	29 (29)
2nd tumor
Negative	23 (76.7)	96 (96)	0.0033
Positive	7 (23.3)	4 (4)
Next-Generation Sequencing status			< 0.0013
Mutasyon positive	13 (76.5)	1 (2.7)
Mutasyon negative	4 (23.5)	35 (97.3)

¹Mann-Whitney U test.

²Pearson ki-kare test.

³Fisher exact test.

IQR: Interquartile range; LN: Lymph node.