Responsive mesoporous silica nanocarriers in glioma therapy: A step forward in overcoming biological barriers

Table 2 Physical properties and hemolytic activity

Ref.	Factors affecting hemolysis	Hemolysis range	Key findings
Yu et al[137]	Size, shape, porosity	10-500 (significant hemolysis at high doses)	Porosity and shape affected hemolysis
Paula et al[138]	Size, pore, surface charge	--	Protein corona and positive charge lowered hemolysis
Joglekar et al[148]	Morphology (spherical/tubular)	Minimal up to 500 µg/mL	Spherical MSNs showed lower hemolysis
Martínez-Carmona et al[165]	Protein interaction	EC50: 8-28 µg/mL (protein-dependent)	Protein corona suppressed hemolysis dose-dependently
Yildirim et al[176]	Surface functionalization with ionic, polar, neutral, and hydrophobic groups	Approximately 100-500 µg/mL	Functionalization with ionic groups reduced hemolysis

MSN: Mesoporous silica nanoparticle.