Extracellular vesicles circular RNA: A new perspective and clinical application potential for mediating chemoresistance in colorectal cancer

Table 2 List of extracellular vesicles-circular RNAs involved in colorectal cancer chemoresistance or chemosensitivity

	EV content	Expression	EV source	Targets/regulators	Function	Drug	Ref.
Chemosensitivity	Circ-FBXW7	Down	Human fetal colon cell culture	MiR-18b-5p	Increases apoptosis, inhibits epithelial-mesenchymal transition, and improves chemosensitivity	OXA	Xu et al[58]
	Circ_0094343	Down	Cell lines (NCM460 and HCT116)	MiR-766-5p/tripartite motif-containing 67	Inhibits the proliferation, clone formation, glycolysis of colorectal cancer cells, and improves chemosensitivity	5-FU, OXA, and DOX	Li et al[59]
Chemoresistance	Circ_0067557	Up	CAFs	Lin28A, Lin28B	Promotes proliferation, migration, invasion, and chemoresistance	5-FU, OXA	Yang et al[25]
	Hsa_circ_0000338	Up	HCT116-R	-	Promotes chemoresistance	5-FU, OXA	Hon et al[49]
	Hsa_circ_0004085	Up	Fusobacterium nucleatum-infected colon cancer cells	GRP78, ATF6p50	Relieves endoplasmic reticulum stress in recipient cells and promotes chemoresistance	5-FU, OXA	Hui et al[60]
	Circ_0000338	Up	Cell lines (SW480/5-FU and HCT116/5-FU)	MiR-217, miR-485-3p	Promotes chemoresistance	5-FU	Zhao et al[61]
	Cric-N4BP2 L2	Up	CAFs	Eukaryotic translation initiation factor 4A3/phosphatidylinositol 3-kinase/protein kinase B/mammalian target of the rapamycin	Aggravates stemness and promotes chemoresistance	OXA	Qu et al[62]
	Hsa_circ_0005963	Up	Serum and cell lines (SW480, HCT116, and HEK293)	MiR-122/pyruvate kinase muscle isozyme M2	Promotes glycolysis and chemoresistance	OXA	Wang et al[63]
	Circ_0001610	Up	Cell lines (DLD1 and HCT15)	MiR-30e-5p	Increases oxidative phosphorylation activity and stemness phenotype in recipient cells leading to chemoresistance	OXA	Deng et al[64]
	Has_circ_0004771	Up	Serum and cell lines (NCM460, SW620, and HCT116)	MiR-653/ZEB2	Promotes chemoresistance	5-FU	Qiao et al[65]
	Circ_0006174	Up	Cell lines (LoVo/DOX, and HCT116/DOX)	MiR-1205/cyclin D2	Promotes chemoresistance	DOX	Zhang et al[66]

CAFs: Cancer-associated fibroblasts; CircRNA: Circular RNA; DOX: Doxorubicin; EV: Extracellular vesicle; OXA: Oxaliplatin; 5-FU: 5-fluorouracil.