Optimizing neoadjuvant chemoradiation in resectable and borderline resectable pancreatic cancer: Evidence-based insights

Table 1 An overview of borderline resectable pancreatic cancer definitions

Criteria	NCCN version 2.2024[19]	MDSCC version 6 (2019)[18]	AHPBA-SSO-SSAT[21]	ASCO[20]	JPS[24]		IAP[23]
					BR-PV	BR-A	BR-PV	BR-A
CA	Solid-tumor contact ≤ 180° or contact > 180° without involvement of the aorta or GDA	No involvement	No involvement	No interface	No tumor contact/invasion	Tumor contact/invasion of less than 180 without showing stenosis/deformity	No tumor contact/invasion	Tumor contact of less than 180 without showing deformity/stenosis
CHA	Solid-tumor contact without extension to CA or hepatic artery bifurcation	Short-segment encasement or abutment of CHA or GDA	GDA encasement up to hepatic artery with either short-segment encasement or direct no tumor contact/invasion abutment of hepatic artery	No interface	No tumor contact/invasion	Tumor contact/invasion without showing tumor contact/invasion of the PHA and/or CA.	No tumor contact/invasion	Tumor contact without showing tumor contact of the PHA and/or CA
SMA	Solid-tumor contact ≤ 180° or solid-tumor contact with variant arterial anatomy	Tumor abutment of ≤ 180°	Tumor contact is not to exceed > 180°	No interface	No tumor contact/invasion	Tumor contact/invasion of less than 180 without showing stenosis/deformity	No tumor contact/invasion	Tumor contact of less than 180 without showing deformity/stenosis
SMV or PV	Solid-tumor contact > 180° or ≤ 180° with contour abnormality or thrombosis of the vein, provided there is a suitable proximal and distal vessel to allow venous resection and reconstruction	Short-segment occlusion with patent vessels above and below the occlusion	Tumor abutment with or without impingement and narrowing of the lumen; encasement without encasement of the nearby arteries; short-segment occlusion with the suitable proximal and distal vessel, allowing safe resection and reconstruction	No interface	Tumor contact/invasion of 180 or more/occlusion, not exceeding the inferior border of the duodenum	No tumor contact/invasion	Tumor contact 180 or greater or bilateral narrowing/occlusion, not exceeding the inferior border of the duodenum	-

NCCN: National Comprehensive Cancer Network; MDSCC: MD-Anderson Cancer Centre; AHPBA-SSO-SSAT: Americas Hepato Pancreatic Biliary Association-Society of Surgical Oncology-Society of the Alimentary Tract; ASCO: American Society of Clinical Oncology; JPS: Japan Pancreas Society; IAP: International Association of Pancreatology; BR: Borderline resectable; GDA: Gastroduodenal artery; CHA: Common hepatic artery; SMA: Superior mesenteric artery; SMV: Superior mesenteric vein; PV: Portal vein; PHA: Proper hepatic artery; CA: Celiac artery.