Impact of propofol on gastrointestinal cancer outcomes: A review of cellular behavior, growth, and metastasis

Table 1 The pharmacokinetic and pharmacodynamic properties of propofol[10]

Properties
Route of administration		Intravenous
Standard induction dose (mg/kg)		1.5-2.5
Onset of action (second)		40-60 (‘one arm brain circulation’)
Duration of action (minute)		3-10
Volume of distribution (L/kg)		5.8
Protein binding		97%-99% (mostly albumin)
Metabolism		Hepatic oxidation and conjugation to sulfate and glucuronide conjugates
Total body clearance (L/hour/kg)		3.2
Half-life	Initial (minute)	Approximately 40
	Terminal (hour)	4-7
	Context-sensitive (day)	1-3 days after a 10-day infusion. The clinical effect of propofol is much shorter
Excretion		Primarily renal