Regulation of matrix metalloproteinase-13 in cancer: Signaling pathways and non-coding RNAs in tumor progression and therapeutic targeting

doi:10.5306/wjco.v16.i6.105996

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Jun 24, 2025 (publication date) through Jun 20, 2025

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jun 24, 2025; 16(6): 105996
Published online Jun 24, 2025. doi: 10.5306/wjco.v16.i6.105996

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Figure 2 Pathophysiological role of matrix metalloproteinase-13 in various diseases. A schematic diagram illustrates the involvement of matrix metalloproteinase-13 (MMP-13) in the development and progression of various diseases. ECM: Extracellular matrix; PKC: Protein kinase C delta; JNK: Jun N-terminal kinase; ERK: Extracellular signal-regulated kinase; NF-κB: Nuclear factor kappa B; CREB: Cyclic adenosine monophosphate-response element binding protein; IL36R: Interleukin 36R; TGF-β3: Transforming growth factor-beta 3; MMP-13: Matrix metalloproteinase-13.

Citation: Chidambaram D, Subashini V, Nanthanalaxmi M, Saranya I, Selvamurugan N. Regulation of matrix metalloproteinase-13 in cancer: Signaling pathways and non-coding RNAs in tumor progression and therapeutic targeting. World J Clin Oncol 2025; 16(6): 105996
URL: https://www.wjgnet.com/2218-4333/full/v16/i6/105996.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i6.105996