Clinical characteristics and prognostic factors in patients with malignant melanoma: A Chinese prospective cohort study

Table 2 Univariate analysis of prognostic factors in patients with malignant melanoma

Variable	Number of death (%)	Mean survival (months) (95%CI)	Median survival (months) (95%CI)	Survival rate (%)			χ2	P value
				1 year	3 years	5 years
Age (years)							17.757	< 0.001
≤ 50	65 (31.55)	57.65 (50.06, 65.24)	87.3 (35.31, 139.29)	78.80	61.03	52.87
51-70	159 (39.36)	50.28 (44.99, 55.57)	37.4 (28.56, 46.24)	77.00	51.92	39.31
≥ 71	74 (49.66)	32.06 (26.17, 37.96)	20.6 (11.26, 29.94)	76.11	36.70	14.68
Sex							0.000	0.988
Female	147 (39.41)	50.07 (44.51, 55.64)	37.4 (28.94, 45.86)	75.14	52.51	39.68
Male	151 (39.12)	48.36 (43.28, 53.44)	37.4 (26.74, 48.06)	79.01	50.75	37.80
Marriage							1.512	0.219
Married	270 (38.74)	51.05 (47.02, 55.09)	37.4 (30.31, 44.49)	77.48	52.64	52.64
Others	28 (45.16)	40.74 (29.29, 52.19)	32.6 (14.22, 50.98)	71.11	42.10	31.57
Ethnicity							0.003	0.960
Han	289 (39.11)	49.6 (45.53, 53.67)	37.4 (30.94, 43.86)	77.09	52.00	38.91
Others	9 (45.00)	46.73 (28.89, 64.58)	15.8 (0, 0)	71.79	47.86	47.86
Types of health insurance							3.290	0.193
Resident health insurance	163 (39.76)	49.98 (44.82, 55.13)	37.6 (29.2, 46)	76.98	52.74	36.35
Employee health insurance	87 (42.23)	44.17 (37.26, 51.08)	29 (17.3, 40.7)	73.27	44.50	37.15
Self-funded and others	48 (33.57)	50.99 (43.58, 58.4)	59.9 (0, 0)	81.06	56.68	45.30
Clinical type classification							4.172	0.383
Cutaneous	49 (35.51)	49.74 (42.04, 57.43)	47.7 (28.89, 66.51)	77.93	57.12	38.88
Acral	135 (37.4)	49.09 (43.74, 54.45)	37 (28.86, 45.14)	82.51	50.95	37.34
Mucosal	59 (43.07)	49.05 (40.16, 57.94)	36.4 (20.62, 52.18)	68.52	48.93	39.63
Ocular	16 (48.48)	42.6 (27.18, 58.01)	27.7 (0, 67.66)	62.04	47.27	31.51
Types of undetermined origin	39 (43.33)	43.22 (34.05, 52.39)	29 (10.84, 47.16)	66.11	45.08	34.88
Combined with other tumors							0.027	0.870
No	289 (39.27)	49.55 (45.39, 53.71)	37.4 (30.44, 44.36)	77.07	51.63	38.77
Yes	9 (39.13)	47.75 (28.64, 66.86)	35.5 (12.09, 58.91)	78.94	48.58	36.43
Underlying Diseases							7.586	0.006
No	238 (38.08)	52.26 (47.85, 56.67)	41 (34.35, 47.65)	77.68	54.93	41.70
Yes	60 (44.78)	33.79 (27.1, 40.47)	22.9 (13.43, 32.37)	71.63	33.97	19.51
Tumor stage							52.591	< 0.001
Ⅰ-Ⅱ	38 (22.09)	68.03 (59.42, 76.64)	0 (0, 0)	88.31	69.98	54.65
Ⅲ	53 (31.93)	52.34 (43.72, 60.97)	43.1 (29.83, 56.37)	82.02	53.95	37.88
Ⅳ	125 (50.00)	33.85 (28.46, 39.23)	15.1 (11.71, 18.49)	58.04	36.67	28.58
Surgical operation							18.223	0.000
No	118 (51.75)	39.6 (33.46, 45.74)	25.9 (18.66, 33.14)	69.78	41.02	26.25
Yes	180 (33.90)	53.42 (48.62, 58.23)	46.2 (33.23, 59.17)	79.77	56.56	44.09
Radiotherapy							0.010	0.921
No	244 (37.95)	49.6 (45.49, 53.7)	37.3 (29.91, 44.69)	77.11	52.14	38.69
Yes	54 (46.55)	47.83 (39.23, 56.44)	37.8 (24.61, 50.99)	76.17	50.86	39.29
Chemotherapy							3.054	0.081
No	192 (39.92)	45.07 (40.43, 49.71)	34 (28.27, 39.73)	76.92	48.32	33.86
Yes	106 (38.13)	54.8 (48.55, 61.06)	43.1 (27, 59.2)	76.52	56.53	44.52
Immunotherapy							1.637	0.441
No	264 (41.64)	50.25 (46.07, 54.44)	37.6 (30.82, 44.38)	77.01	52.81	39.28
Yes	34 (27.42)	28.44 (23.16, 33.71)	23 (15.5, 30.5)	73.91	39.06	39.06
Targeted therapy							1.042	0.594
No	290 (39.84)	49.58 (45.5, 53.67)	37.3 (30.73, 43.87)	76.86	51.62	38.32
Yes	8 (26.67)	52.36 (34.14, 70.58)	80.5 (0, 0)	76.06	57.04	57.04
Use of interleukins							0.877	0.645
No	276 (38.82)	49.67 (45.47, 53.87)	37.3 (30.33, 44.27)	76.60	51.46	39.24
Yes	22 (46.81)	46.19 (35.54, 56.84)	39.5 (25.55, 53.45)	83.72	52.64	19.19
Use of interferon							3.320	0.068
No	265 (40.03)	46.94 (42.73, 51.15)	36.9 (29.84, 43.96)	75.77	51.00	37.53
Yes	33 (34.38)	58.46 (48.01, 68.9)	59.9 (35.1, 84.7)	84.27	57.77	46.36
Use of antiangiogenic drugs							0.796	0.672
No	284 (39.23)	49.63 (45.53, 53.73)	37.3 (30.54, 44.06)	77.67	51.53	39.07
Yes	14 (41.18)	45.6 (31.17, 60.04)	39.8 (14.15, 65.45)	65.42	50.10	41.75
Platelet count							16.627	< 0.001
Normal	245 (37.98)	49.8 (45.27, 54.32)	37.4 (29.97, 44.83)	78.13	52.27	38.93
Low	30 (40.00)	55.91 (44.92, 66.9)	42.9 (0, 0)	75.13	54.27	48.24
High	14 (50.00)	16.57 (9.99, 23.16)	10.5 (5.35, 15.65)	38.93	29.20	29.20
Lactate dehydrogenase							50.549	< 0.001
Normal	169 (34.28)	53 (48.26, 57.73)	44.6 (31.79, 57.41)	83.14	57.15	43.64
Low	2 (33.33)	43.96 (27.04, 60.88)	42.9 (0, 86.94)	80.00	40.00	40.00
High	70 (52.24)	30.07 (21.38, 38.77)	12.4 (7.35, 17.45)	50.99	29.40	16.38

The raw data were absent for platelet count in 11 patients and for lactate dehydrogenase level in 126 patients.