Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas

Figure 2 Histopathological features of mismatch repair deficient/microsatellite instability-high colorectal cancers. A: Moderately differentiated adenocarcinoma with expansile pattern of invasion; B: Low tumor budding (arrows); C: Peritumoral lymphocytic response or Cron’s like lymphoid reaction (arrows); D: Marked intraepithelial tumor infiltrating lymphocytes; E: Loss of MutL homolog 1 protein immune expression; F: Intact MutS homolog 2 protein immune expression; G: Intact MutS homolog 6 protein immune expression; E and H: Loss of postmeiotic segregation increased 2 protein immune expression (note the positive internal control i.e. nuclear staining of MutL homolog 1 or postmeiotic segregation increased 2 in stromal cells or lymphocytes).