Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas

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Jun 24, 2025 (publication date) through Jun 23, 2025

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jun 24, 2025; 16(6): 104243
Published online Jun 24, 2025. doi: 10.5306/wjco.v16.i6.104243

Table 1 Clinical characteristics of colorectal cancer patients included in the study, n (%)

Characteristics	Total (n = 223)	MMR-D/MSI-H (n = 87) (39.01%)	MMR-P/MSS (n = 136) (60.99%)	P value
Age				0.207
≤ 40 years	35 (15.7)	17 (19.5)	18 (13.2)
> 40 years	188 (84.3)	70 (80.5)	118 (86.8)
Sex				0.243
Male	146 (65.5)	61 (70.1)	85 (62.5)
Female	77 (34.5)	26 (29.9)	51 (37.5)
Location				< 0.001
Right	130 (58.3)	69 (79.3)	61 (44.9)
Left	93 (41.7)	18 (20.7)	75 (55.1)
Stage				< 0.001
I	14 (6.2)	6 (6.9)	8 (5.9)
II	126 (56.5)	67 (77)	59 (43.4)
III	83 (37.2)	14 (16.1)	69 (50.7)
Overall survival at five years	-	92%	71%	< 0.001

MMR-D: Mismatch repair deficient; MSI-H: Microsatellite instability-high; MMR-P: Mismatch repair proficient; MSS: Microsatellite stable.

Citation: Mehta A, Bansal D, Tripathi R, Anoop V. Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas. World J Clin Oncol 2025; 16(6): 104243
URL: https://www.wjgnet.com/2218-4333/full/v16/i6/104243.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i6.104243