Diagnosis and treatment of metachronous multiple primary carcinoma: A case report and review of literature

Table 2 Reports of metachronous multiple primary carcinoma of breast cancer and non-Hodgkin lymphoma and treatment strategies

Year	Patient description	Primary carcinoma	Second primary malignancy	Follow up management	Ref.
1983	A 52-year-old premenopausal white woman	Breast carcinoma	Aggressive, large cell lymphoma of the ileum (occur to twelve years after diagnosis and five years after the start of chemotherapy)	Treated for breast carcinoma with postoperative adjuvant chest wall irradiation, followed four and seven years later with therapy to spinal ports for palliation of metastatic disease. For the next three and a half years, she received oral cyclophosphamide on a daily basis to a total of more than 110 g	[12]
1989	A 51-year-old woman	Malignant lymphoma of the breast	Scirrhous carcinoma (two years after the operation)	For primary carcinoma modified radical mastectomy (Patey's method), in combination with chemotherapy (Cyclophosphamide, Vincristine, Prednisolone). for scirrhous carcinoma performed a modified radical mastectomy (Auchincloss' method), followed by chemotherapy (Tegafur)	[13]
1990	A 53-year-old female	Breast cancer (1980)	Malignant lymphoma of diffuse, small cell type (lymphoplasmacytic) (1988)	Radical mastectomy, followed by irradiation was performed in 1980	[14]
2002	A 70-year-old woman	A history of non-Hodgkin’s lymphoma and melanoma	Moderately differentiated infiltrating ductal carcinoma	Underwent a right breast lumpectomy with right axillary lymph node dissection	[15]
2015	A 55-year-old Caucasian woman	Simultaneous ductal carcinoma in situ of the right breast, and follicular lymphoma involving an inguinal lymph node and the left breast	Multifocal ductal carcinoma of the left breast and reappearance of the lymphoma in the left axillary lymph nodes (2 years later)	The patient underwent local excision and radiotherapy for the ductal carcinoma in situ, while a watch and wait strategy was adopted for the lymphoma. Two years later, underwent bilateral mastectomy, left sentinel node biopsy, and chemotherapy	[16]
2021	A 58-year-old woman	Breast cancer	Malignant lymphoma and colon cancer (2 years later)	Maliqnant lymphoma and colon cancer that occurred during breast cancer treatment	[17]