Treatment strategies targeting the phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin pathway against triple-negative breast cancer

Figure 2 The key points discussed in this study. TNBC: Triple negative breast cancer; PI3K: Phosphoinositide 3-kinase; Akt: Protein kinase B; mTOR: Mechanistic target of rapamycin; TYMS: Thymidylate synthase; GBP2: Guanylate-binding protein 2; ACTL8: Actin-like protein 8; OPN: Osteopontin; ROR2: Receptor tyrosine kinase-like orphan receptor 2; Nrf3: Nuclear factor erythroid-2-like factor 3; QC: Quercetin; PAB: Pseudolaric acid B; Tan IIA: Tanshinone IIA; BJE: Brucea javanica seed; RTEs: Radix tetrastigma extracts; PIP: Piperine; BBM: Berbamine; HHT: Homoharringtonine.