Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression

Figure 6 Subcutaneous tumor formation experiment in nude mice. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. A: Representative images of subcutaneous tumors; B and C: Tumor volume growth curve and tumor weight measurements; D: Hematoxylin and eosin staining of subcutaneous tumors from four groups; E: Immunohistochemistry of subcutaneous tumors from four groups (Ki-67); F: Protein expression of the epithelial-mesenchymal transition and Janus kinase 2/signal transducer and activator of transcription 3 pathway with addition of AG490 from subcutaneous tumors. YY1: Yin Yang 1; JAK2: Janus kinase 2; STAT3: Signal transducer and activator of transcription 3; pJAK2: Phosphorylated Janus kinase 2; pSTAT3: Phosphorylated signal transducer and activator of transcription 3; JASPAR: Joint Array for Public Research.