Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression

Figure 4 Yin Yang 1 enhances malignant phenotypes in gastric cancer cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. A: Western blotting confirmed the transfection efficiency of Yin Yang 1 (YY1) lentivirus; B and C: Colony formation assays and 5-ethynyl-2’-deoxyuridine assessing the impact of YY1 knockdown and overexpression on proliferation of AGS cells; D and E: Wound healing and Transwell assays evaluating the effects of YY1 knockdown and overexpression on the invasion and migration of AGS cells. EdU: 5-Ethynyl-2’-deoxyuridine; YY1: Yin Yang 1; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; sh: Short hairpin.