Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression

Figure 2 Yin Yang 1 is upregulated in Helicobacter pylori-induced gastritis. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. A: Protein expression of Yin Yang 1 (YY1) in GES-1 cell lines cocultured with Helicobacter pylori (H. pylori) strains ATCC26695, ATCC43504, and HPWT; B: Immunohistochemistry analysis of differential YY1 and N-cadherin expression in chronic nonatrophic gastritis, atrophic gastritis, and intestinal metaplasia tissues; C: Schematic diagram of a mouse model of H. pylori infection (gastritis); D: Representative images of gastric mucosa in mice with gastritis, assessed by hematoxylin and eosin staining, and H. pylori expression detected by Warthin-Starry staining; E and F: YY1 and N-cadherin expression in gastric tissues of mice 12 weeks and 36 weeks post-H. pylori infection was analyzed by Western blotting and immunohistochemistry. YY1: Yin Yang 1; AG: Atrophic gastritis; IM: Intestinal metaplasia; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.