Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression

Table 2 Univariate and multivariate survival analyses for association between clinicopathological parameters and YY1 expression

Parameter	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Gender (male vs female)	1.036 (0.592-1.815)	0.901	-	-
Age (< 60 years vs ≥ 60 years)	0.882 (0.496-1.567)	0.668	-	-
Tumor location (upper vs middle + lower)	0.837 (0.478-1.467)	0.535	-	-
Tumor size (< 6 cm vs ≥ 6 cm)	1.344 (0.820-2.202)	0.241	-	-
Differentiation (well + moderate vs poor + undifferentiated)	3.338 (1.744-6.387)	< 0.001	2.152 (1.108-4.181)	0.024
pT stage (T1-T2 vs T3-T4)	4.821 (2.292-10.138)	< 0.001	2.568 (1.169-5.642)	0.019
Lymph node metastasis (absent vs present)	4.682 (2.378-9.219)	< 0.001	3.067 (1.493-6.300)	0.002
pTNM stage (I-II vs III-IV)	3.818 (2.330-6.255)	< 0.001	2.211 (1.306-3.724)	0.003
YY1 expression (low vs high)	1.966 (1.106-3.495)	0.021	1.315 (1.054-1.552)	0.045

HR: Hazard ratio; CI: Confidence interval; YY1: Yin Yang 1; pTNM: Pathologic tumor-node-metastasis.