Expanding the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A multicenter study on uncommon peritoneal malignancies

doi:10.5306/wjco.v16.i12.112443

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Clin Oncol. Dec 24, 2025; 16(12): 112443
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112443

Table 1 Patient characteristics

	n (%)	PCI median
Females	47 (78.3)
BMI (kg/m²; median)	26
Synchronous PM	26 (43.3)
Neoadjuvant chemotherapy	18 (69.2)
Adjuvant chemotherapy	22 (84.6)
Both	17 (65.4)
Metachronous PM	34 (56.7)
Neoadjuvant chemotherapy	8 (23.5)
Adjuvant chemotherapy	24 (70.6)
Both	3 (8.8)
ASA
1	17 (28.3)
2	34 (56.7)
3	9 (15)
PCI (median)	13
Primary origin of neoplasia
Uterus	21 (35)	13
Breast	8 (13.4)	19
Sarcoma	5 (8.4)	16
Small bowel	6 (10)	14
Liver	4 (6.6)	9
Pancreas	4 (6.6)	8
Biliary tract	3 (5)	2
MPM	3 (5)	12
Miscellaneous¹	6 (10)	7.5

¹Miscellaneous includes: Ovarian carcinosarcoma; gastrointestinal stromal tumor (previously treated with TKI, resistant); 2 jejunal NET; desmoplastic small round cell tumor; malignant Pheochromocytoma.

BMI: Body mass index; PM: Peritoneal metastases; PCI: Peritoneal Cancer Index; MPM: Malignant peritoneal mesothelioma.

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Citation: Framarini M, D'Acapito F, Lippolis PV, Di Giorgio A, Di Pietrantonio D, Sommariva A, Sammartino P. Expanding the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A multicenter study on uncommon peritoneal malignancies. World J Clin Oncol 2025; 16(12): 112443
URL: https://www.wjgnet.com/2218-4333/full/v16/i12/112443.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i12.112443

Framarini M, D'Acapito F, Lippolis PV, Di Giorgio A, Di Pietrantonio D, Sommariva A, Sammartino P. Expanding the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A multicenter study on uncommon peritoneal malignancies. World J Clin Oncol 2025; 16(12): 112443 [PMID: 41480175 DOI: 10.5306/wjco.v16.i12.112443]

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