Expression patterns and clinical implications of chaperonin subunit 3 mRNA and protein in laryngeal squamous cell carcinoma

doi:10.5306/wjco.v16.i12.112161

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Dec 24, 2025; 16(12): 112161
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112161

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Figure 6 Immunohistochemical verification of chaperonin-containing TCP1 subunit 3 protein in laryngeal squamous cell carcinoma tissue. A and B: Chaperonin-containing TCP1 subunit 3 (CCT3) protein show negative intensity in non-cancerous squamous epithelium; C and D: CCT3 protein show positive intensity in the cytoplasm of laryngeal squamous cell carcinoma cell; E: The expression of CCT3 protein is significantly higher in laryngeal squamous cell carcinoma than in non-cancerous squamous epithelium; F: CCT3 protein has perfect diagnostic performance, accurately distinguishing between laryngeal squamous cell carcinoma and non-cancerous squamous epithelium. CCT3: Chaperonin-containing TCP1 subunit 3; LSCC: Laryngeal squamous cell carcinoma; AUC: Area under the curve.

Citation: Mo BY, Wen JY, Chen GQ, Ling JW, He H, Qin ZL, Tian FY, Li Q, Li B, Li JD, He RQ, Qin DY, Li ZY, Chen G, Mo CH, Chen C, Yin SH, Yang L. Expression patterns and clinical implications of chaperonin subunit 3 mRNA and protein in laryngeal squamous cell carcinoma. World J Clin Oncol 2025; 16(12): 112161
URL: https://www.wjgnet.com/2218-4333/full/v16/i12/112161.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i12.112161

Mo BY, Wen JY, Chen GQ, Ling JW, He H, Qin ZL, Tian FY, Li Q, Li B, Li JD, He RQ, Qin DY, Li ZY, Chen G, Mo CH, Chen C, Yin SH, Yang L. Expression patterns and clinical implications of chaperonin subunit 3 mRNA and protein in laryngeal squamous cell carcinoma. World J Clin Oncol 2025; 16(12): 112161 [PMID: 41480162 DOI: 10.5306/wjco.v16.i12.112161]

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