Expression patterns and clinical implications of chaperonin subunit 3 mRNA and protein in laryngeal squamous cell carcinoma

Figure 3 Chaperonin-containing TCP1 subunit 3 mRNA was significantly increased and has a strong discriminatory performance between laryngeal squamous cell carcinoma and non-cancerous tissue. A: The expression level of chaperonin-containing TCP1 subunit 3 mRNA in the Laryngeal squamous cell carcinoma group was significantly higher than that in the control group overall (the standardized mean difference = 1.32, 95% confidence interval: 0.79-1.84), but there was significant heterogeneity among the studies (I² = 75%); B: The summary receiver operating characteristic curve indicates that the discriminative performance of chaperonin-containing TCP1 subunit 3 mRNA is strong (area under the curve = 0.93), with sensitivity and specificity of 0.84 and 0.91, respectively. SMD: Standardized mean difference; CI: Confidence interval; SROC: Summary receiver operating characteristic; SENS: Sensitivity; SPEC: Specificity; AUC: Area under the curve.