©The Author(s) 2025.
World J Clin Oncol. Dec 24, 2025; 16(12): 111544
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111544
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111544
Table 3 Subgroup analysis of group-specific component gene rs4588 polymorphism and nasopharyngeal carcinoma risk, n (%)
| Subgroup | Genotype | Case group | Control group | Odds ratio (95%CI) | P value |
| Gender | |||||
| Male | GG | 112 (43.8) | 192 (49.9) | 1.00 (reference) | |
| GT | 108 (42.2) | 160 (41.6) | 1.16 (0.83-1.61) | 0.389 | |
| TT | 36 (14.0) | 33 (8.5) | 1.87 (1.11-3.15) | 0.019 | |
| Female | GG | 44 (42.3) | 80 (48.5) | 1.00 (reference) | |
| GT | 44 (42.3) | 70 (42.4) | 1.14 (0.68-1.92) | 0.615 | |
| TT | 16 (15.4) | 15 (9.1) | 1.94 (0.88-4.28) | 0.099 | |
| Tumor type | |||||
| Squamous cell carcinoma | GG | 120 (43.5) | 272 (49.5) | 1.00 (reference) | |
| GT | 116 (42.0) | 230 (41.8) | 1.14 (0.84-1.55) | 0.391 | |
| TT | 40 (14.5) | 48 (8.7) | 1.89 (1.19-3.00) | 0.007 | |
| Other types | GG | 36 (42.9) | 272 (49.5) | 1.00 (reference) | |
| GT | 36 (42.9) | 230 (41.8) | 1.18 (0.72-1.94) | 0.506 | |
| TT | 12 (14.2) | 48 (8.7) | 1.89 (0.92-3.88) | 0.084 |
- Citation: Liu L, Shi DY, Tan J, Xu S, Liu CR. Group-specific component and 25-hydroxylase gene polymorphisms in nasopharyngeal carcinoma: Associations with susceptibility and radiotherapy response. World J Clin Oncol 2025; 16(12): 111544
- URL: https://www.wjgnet.com/2218-4333/full/v16/i12/111544.htm
- DOI: https://dx.doi.org/10.5306/wjco.v16.i12.111544