Perioperative immunotherapy in gastric cancer in the spotlight

doi:10.5306/wjco.v16.i12.110988

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Dec 24, 2025; 16(12): 110988
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.110988

Table 2 Neoadjuvant therapy: Overview of pivotal clinical trials investigating neoadjuvant therapy in gastroesophageal cancers

Trial name	Disease subtype	Strategy	R0 resection rate	OS
EORTC trial (2010)	G/GEJ adenocarcinoma	Neoadjuvant CT vs surgery	81.9% (CT) vs 66.7%; P = 0.036	Median OS not improved
EORTC trial (2010)	G/GEJ adenocarcinoma	Neoadjuvant CT vs surgery	pCR: 7.1% (CT)	HR OS: 0.84 (0.52-1.35); P = 0.466
CROSS trial (2012)	Mostly distal esophagus (58%)	Neoadjuvant CRT vs surgery	92% (CRT) vs 69%	Median OS: 49.4 months (CRT) vs 24.0 months
CROSS trial (2012)	Mostly adenocarcinoma (75%)	Neoadjuvant CRT vs surgery	pCR: 29% (CRT)	HR OS: 0.657 (0.495-0.871); P = 0.003

R0: Complete resection with no tumor within 1mm; OS: Overall survival; G/GEJ: Gastric and gastroesophageal junction; CRT: Chemoradiotherapy; HR: Hazard ratio; CT: Chemotherapy; pCR: Complete pathological response.

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Citation: Pernomian LS, Teixeira MF, Araujo RL, Serrano Uson Junior PL. Perioperative immunotherapy in gastric cancer in the spotlight. World J Clin Oncol 2025; 16(12): 110988
URL: https://www.wjgnet.com/2218-4333/full/v16/i12/110988.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i12.110988

Pernomian LS, Teixeira MF, Araujo RL, Serrano Uson Junior PL. Perioperative immunotherapy in gastric cancer in the spotlight. World J Clin Oncol 2025; 16(12): 110988 [PMID: 41480178 DOI: 10.5306/wjco.v16.i12.110988]

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