Immune regulation of Chidamide-induced Linc01010 accumulation in breast cancer cell death

Figure 1 The accumulation of Linc01010 induced by Chidamide was associated with the activation of the mitogen-activated protein kinases pathway and the initiation of the programmed death-1/programmed death-ligand 1 checkpoint. A: According to our previous RNA high-throughput sequencing data, we applied Kyoto Encyclopedia of Genes and Genomes analysis to try to reveal the relevant signaling pathways; B: The quantitative polymerase chain reaction was used to investigate the mRNA changes of related factors in breast cancer cells; C: Northern blot was utilized to investigate the actual RNA amount of Linc01010 in Chidamide-treated cells. The mean ± SD for three independent experiments and analyzed using Statistical Package for Social Science software, 20 μM Chidamide vs Basal at ^aP < 0.05. CHid: Chidamide; KEGG: Kyoto Encyclopedia of Genes and Genomes; LncRNAs: Long chain non-coding RNAs; MKK6: Mitogen-activated protein kinase kinase 6; PD-L: Programmed death-ligand; PD-1: Programmed death-1.