Single-nucleotide variants in microRNAs associated with breast cancer in women from western Mexico

Table 5 Association between rs73262897 with histological and immunohistochemical subtypes of breast cancer, n (%)

rs73262897 G>A		Cases	Control	Model comparison		OR (95%CI)	P value
Breast cancer ductal
Genotype	-	n = 37	n = 215	-	G/G vs G/A	1.0970 (0.4683-2.5696)	0.8311
	G/G	29 (78)	171 (80)	MC	G/G vs A/A	-	-
	G/A	8 (22)	43 (20)	-	G vs A	1.0370 (0.4678-2.2990)	0.9287
	A/A	0 (0)	1 (0)	Do	G/G vs G/A + A/A	-	-
Allele	-			Re	G/G + G/A vs A/A	-	-
	G	66 (89)	385 (90)	OD	G/G + A/A vs G/A	-	-
	A	8 (11)	45 (10)	L-ad		-	-
Breast cancer lobular
Genotype	-	n = 13	n = 215	-	G/G vs G/A	-	-
	G/G	10 (77)	171 (80)	MC	G/G vs A/A	-	-
	G/A	3 (23)	43 (20)	-	G vs A	-	-
	A/A	0 (0)	1 (0)	Do	G/G vs G/A + A/A	-	-
Allele	-			Re	G/G + G/A vs A/A	-	-
	G	23 (88)	385 (90)	OD	G/G + A/A vs G/A	-	-
	A	3 (12)	45 (10)	L-ad		-	-
Breast cancer mixed
Genotype	-	n = 5	n = 215	-	G/G vs G/A	-	-
	G/G	2 (40)	171 (80)	MC	G/G vs A/A	-	-
	G/A	3 (60)	43 (20)	-	G vs A	-	-
	A/A	0 (0)	1 (0)	Do	G/G vs G/A + A/A	-	-
Allele	-			Re	G/G + G/A vs A/A	-	-
	G	7 (70)	385 (90)	OD	G/G + A/A vs G/A	-	-
	A	3 (30)	45 (10)	L-ad		-	-
Breast cancer HR+/LA
Genotype	-	n = 36	n = 215	-	G/G vs G/A	1.5295 (0.6857-3.4119)	0.2992
	G/G	26 (72)	171 (80)	MC	G/G vs A/A	-	-
	G/A	10 (28)	43 (20)	-	G vs A	1.3799 (0.6611-2.8802)	0.3910
	A/A	0 (0)	1 (0)	Do	G/G vs G/A + A/A	-	-
Allele	-			Re	G/G + G/A vs A/A	-	-
	G	62 (86)	385 (90)	OD	G/G + A/A vs G/A	-	-
	A	10 (14)	45 (10)	L-ad		-	-
Breast cancer TP/LB
Genotype	-	n = 13	n = 215	-	G/G vs G/A	-	-
	G/G	10 (77)	171 (80)	MC	G/G vs A/A	-	-
	G/A	3 (23)	43 (20)	-	G vs A	-	-
	A/A	0 (0)	1 (0)	Do	G/G vs G/A + A/A	-	-
Allele	-			Re	G/G + G/A vs A/A	-	-
	G	23 (88)	385 (90)	OD	G/G + A/A vs G/A	-	-
	A	3 (12)	45 (10)	L-ad		-	-
Breast cancer HER2+
Genotype	-	n = 9	n = 215	-	G/G vs G/A	-	-
	G/G	7 (78)	171 (80)	MC	G/G vs A/A	-	-
	G/A	2 (22)	43 (20)	-	G vs A	-	-
	A/A	0 (0)	1 (0)	Do	G/G vs G/A + A/A	-	-
Allele	-			Re	G/G + G/A vs A/A	-	-
	G	16 (89)	385 (90)	OD	G/G + A/A vs G/A	-	-
	A	2 (11)	45 (10)	L-ad		-	-
Breast cancer TN
Genotype	-	n = 5	n = 215	-	G/G vs G/A	-	-
	G/G	5 (100)	171 (80)	MC	G/G vs A/A	-	-
	G/A	0 (0)	43 (20)	-	G vs A	-	-
	A/A	0 (0)	1 (0)	Do	G/G vs G/A + A/A	-	-
Allele	-			Re	G/G + G/A vs A/A	-	-
	G	10 (100)	385 (90)	OD	G/G + A/A vs G/A	-	-
	A	0 (0)	45 (10)	L-ad		-	-

^aP < 0.05.

OR: Odds ratio; CI: Confidence interval; MC: Multiple comparison; Do: Dominant model; Re: Recessive model; OD: Over-dominant model; L-ad: Log-additive model; HR+: Hormone receptor positive; LA: Luminal A; TP: Triple positive; LB: Luminal B; HER2+: Human epidermal growth factor 2 positive.