Single-nucleotide variants in microRNAs associated with breast cancer in women from western Mexico

Table 4 Association between rs2682818 with histological and immunohistochemical subtypes of breast cancer, n (%)

rs2682818 C>A		Cases	Control	Model comparison		OR (95%CI)	P value
Breast cancer ductal
Genotype	-	n = 37	n = 215	-	C/C vs C/A	0.1215 (0.0162-0.9129)	0.0405a
	C/C	36 (97)	175 (81)	MC	C/C vs A/A	-	-
	C/A	1 (3)	40 (19)	-	C vs A	0.1336 (0.0181-0.9869)	0.0485a
	A/A	0 (0)	0 (0)	Do	C/C vs C/A + A/A	-	-
Allele				Re	C/C+C/A vs A/A	-	-
	C	73 (99)	390 (91)	OD	C/C+A/A vs C/A	-	-
	A	1 (1)	40 (9)	L-ad		-	-
Breast cancer lobular
Genotype	-	n = 13	n = 215	-	C/C vs C/A	-	-
	C/C	12 (92)	175 (81)	MC	C/C vs A/A	-	-
	C/A	1 (8)	40 (19)	-	C vs A	-	-
	A/A	0 (0)	0 (0)	Do	C/C vs C/A + A/A	-	-
Allele	-			Re	C/C+C/A vs A/A	-	-
	C	25 (96)	390 (91)	OD	C/C+A/A vs C/A	-	-
	A	1 (4)	40 (9)	L-ad		-	-
Breast cancer mixed
Genotype	-	n = 5	n = 215	-	C/C vs C/A	-	-
	C/C	5 (100)	175 (81)	MC	C/C vs A/A	-	-
	C/A	1 (8)	40 (19)	-	C vs A	-	-
	A/A	0 (0)	0 (0)	Do	C/C vs C/A + A/A	-	-
Allele	-			Re	C/C + C/A vs A/A	-	-
	C	10 (100)	390 (91)	OD	C/C + A/A vs C/A	-	-
	A	0 (0)	40 (9)	L-ad		-	-
Breast cancer HR+/LA
Genotype	-	n = 36	n = 215	-	C/C vs C/A	0.1250 (0.0166-0.9397)	0.0433a
	C/C	35 (97)	175 (81)	MC	C/C vs A/A	-	-
	C/A	1 (3)	40 (19)	-	C vs A	0.1373 (0.0186-1.0151)	0.0517
	A/A	0 (0)	0 (0)	Do	C/C vs C/A + A/A	-	-
Allele	-			Re	C/C + C/A vs A/A	-	-
	C	71 (99)	390 (91)	OD	C/C + A/A vs C/A	-	-
	A	1 (1)	40 (9)	L-ad		-	-
Breast cancer TP/LB
Genotype	-	n = 13	n = 215	-	C/C vs C/A	-	-
	C/C	12 (92)	175 (81)	MC	C/C vs A/A	-	-
	C/A	1 (8)	40 (19)	-	C vs A	-	-
	A/A	0 (0)	0 (0)	Do	C/C vs C/A + A/A	-	-
Allele	-			Re	C/C + C/A vs A/A	-	-
	C	25 (96)	390 (91)	OD	C/C + A/A vs C/A	-	-
	A	1 (4)	40 (9)	L-ad		-	-
Breast cancer HER2+
Genotype	-	n = 9	n = 215	-	C/C vs C/A	-	-
	C/C	8 (89)	175 (81)	MC	C/C vs A/A	-	-
	C/A	1 (11)	40 (19)	-	C vs A	-	-
	A/A	0 (0)	0 (0)	Do	C/C vs C/A + A/A	-	-
Allele	-			Re	C/C + C/A vs A/A	-	-
	C	17 (94)	390 (91)	OD	C/C + A/A vs C/A	-	-
	A	1 (6)	40 (9)	L-ad		-	-
Breast cancer TN
Genotype	-	n = 5	n = 215	-	C/C vs C/A	-	-
	C/C	5 (100)	175 (81)	MC	C/C vs A/A	-	-
	C/A	0 (0)	40 (19)	-	C vs A	-	-
	A/A	0 (0)	0 (0)	Do	C/C vs C/A + A/A	-	-
Allele	-			Re	C/C + C/A vs A/A	-	-
	C	10 (100)	390 (91)	OD	C/C + A/A vs C/A	-	-
	A	0 (0)	40 (9)	L-ad		-	-

^aP < 0.05.

OR: Odds ratio; CI: Confidence interval; MC: Multiple comparison; Do: Dominant model; Re: Recessive model; OD: Over-dominant model; L-ad: Log-additive model; HR+: Hormone receptor positive; LA: Luminal A; TP: Triple positive; LB: Luminal B; HER2+: Human epidermal growth factor 2 positive.