Single-nucleotide variants in microRNAs associated with breast cancer in women from western Mexico

Table 2 rs11614913, rs2682818 and rs73262897 allelic and genotypic frequencies of patients with breast cancer and their association with its development in western Mexican population according to the genetic models, n (%)

Genetic model	Genotypes	BrC cases (n = 71)	Controls (n = 215)	OR	95%CI	P value
rs11614913 C>T
MC	C/C	27 (38)	77 (36)	1.00	-	-
	C/T	26 (37)	102 (47)	0.7296	0.3932-1.3439	0.3091
	T/T	18 (25)	36 (17)	1.4259	0.6970-2.9171	0.3312
Do	C/C	27 (38)	77 (36)	1.00	-	-
	C/T + T/T	44 (62)	138 (64)	0.9093	0.5223-1.5829	0.7367
Re	C/C + C/T	53 (75)	179 (83)	1.00	-	-
	T/T	18 (25)	36 (17)	1.6887	0.8873-3.2173	0.1105
OD	C/C + T/T	45 (63)	113 (53)	1.00	-	-
	C/T	26 (37)	102 (47)	0.6401	0.3685-1.1117	0.1132
L-ad	-	-	-	0.89	0.61-1.28	0.52
	Allele
	C	80 (56)	256 (60)	0.89	0.7770-1.6732	0.5024
	T	62 (44)	174 (40)
rs2682818 C>A
MC	C/C	67 (94)	175 (81)	1.00	-	-
	C/A	4 (6)	40 (19)	0.2612	0.0900-0.7582	0.0135a,b
	A/A	0 (0)	0 (0)	ND	ND	ND
	Allele
	C	138 (97)	390 (91)	0.2826	0.0993-0.8044	0.0179a,b
	A	4 (3)	40 (9)
rs73262897 G>A
MC	G/G	54 (76)	171 (79.5)	1.00	-	-
	G/A	17 (24)	43 (20)	1.2519	0.6605-2.3730	0.4910
	A/A	0 (0)	1 (0.5)	ND	ND	ND
	Allele
	G	125 (88)	385 (90)	1.1636	0.6428-2.1061	0.6168
	A	17 (12)	45 (10)

^aP < 0.05.

^bP < 0.025 Bonferroni correction.

Genetics models of rs2682818 and rs73262897 could not be analyzed because of the absence of the genotype A/A and A/A, respectively, in breast cancer cases. BrC: Breast cancer; OR: Odds ratio; CI: Confidence interval; MC: Multiple comparison; Do: Dominant model; Re: Recessive model; OD: Over-dominant model; L-ad: Log-additive model; ND: Not determined.