Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing

doi:10.5306/wjco.v16.i11.111983

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Nov 24, 2025; 16(11): 111983
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.111983

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Figure 5 Integrated analysis of type of mutations, their frequencies in accelerated-phase myeloid leukemia, initial/blast crisis chronic myeloid leukemia, initial association with type of cancer and relevant Food and Drug Administration-approved drug for repurposing. AML: Acute myeloid leukemia; AP-CML: Accelerated-phase myeloid leukemia, initial; APR-246: Eprenetapopt; BC-CML: Blast crisis chronic myeloid leukemia; BCL2: B-cell lymphoma 2; BRCA: Breast cancer susceptibility gene; CBL: Casitas B-cell lineage; CLL: Chronic lymphocytic leukemia; DNMT3A: DNA (cytosine-5)-methyltransferase 3 A; EGFR: Epidermal growth factor receptor; JAK: Janus kinase; MDS: Myelodysplastic syndrome; MPN: Myeloproliferative neoplasms; NPM1: Nucleophosmin 1; NSCLC: Non-small-cell lung cancer; PV: Polycythemia vera.

Citation: AlGarni A, Alanazi N, AlMukhaylid S, Alqahtani S, Almasoudi H, Samir Taleb Y, Alkhamis N, Shaheen S, Haji Siyal A, Aleem A, Naeem R, Shammas MA, Saglio G, Alroweilly D, Hussain A, Iqbal Z. Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing. World J Clin Oncol 2025; 16(11): 111983
URL: https://www.wjgnet.com/2218-4333/full/v16/i11/111983.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i11.111983

AlGarni A, Alanazi N, AlMukhaylid S, Alqahtani S, Almasoudi H, Samir Taleb Y, Alkhamis N, Shaheen S, Haji Siyal A, Aleem A, Naeem R, Shammas MA, Saglio G, Alroweilly D, Hussain A, Iqbal Z. Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing. World J Clin Oncol 2025; 16(11): 111983 [PMID: 41355924 DOI: 10.5306/wjco.v16.i11.111983]

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