Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing

doi:10.5306/wjco.v16.i11.111983

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Clin Oncol. Nov 24, 2025; 16(11): 111983
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.111983

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Figure 1 Flowchart summarizing the integrated experimental and computational pipeline used in this study. ANOVA: Analysis of variance; BC-CML: Blast crisis chronic myeloid leukemia; COSMIC: Catalogue of Somatic Mutations in Cancer; DS: DrugScore; GATK: Genome Analysis Toolkit; GScore: GeneScore; NMF: Non-negative matrix factorization; PCA: Principal component analysis; VEP: Variant Effect Predictor.

Citation: AlGarni A, Alanazi N, AlMukhaylid S, Alqahtani S, Almasoudi H, Samir Taleb Y, Alkhamis N, Shaheen S, Haji Siyal A, Aleem A, Naeem R, Shammas MA, Saglio G, Alroweilly D, Hussain A, Iqbal Z. Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing. World J Clin Oncol 2025; 16(11): 111983
URL: https://www.wjgnet.com/2218-4333/full/v16/i11/111983.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i11.111983

AlGarni A, Alanazi N, AlMukhaylid S, Alqahtani S, Almasoudi H, Samir Taleb Y, Alkhamis N, Shaheen S, Haji Siyal A, Aleem A, Naeem R, Shammas MA, Saglio G, Alroweilly D, Hussain A, Iqbal Z. Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing. World J Clin Oncol 2025; 16(11): 111983 [PMID: 41355924 DOI: 10.5306/wjco.v16.i11.111983]

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