Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Nov 24, 2025; 16(11): 111983
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.111983

Table 4 Blast crisis chronic myeloid leukemia clusters integrating mutation biology and therapeutic guidance

Cluster	Key mutations	Catalogue of Somatic Mutations in Cancer signatures	Processes	Drugs
Cluster 1	Breast cancer susceptibility gene 2, TP53	S3, S5	Homologous recombination deficiency	Olaparib, nutlin-3
Cluster 2	Isocitrate dehydrogenase 1/2, ten-eleven translocation 2	S1, S2	Methylation shift	Ivosidenib, azacitidine
Cluster 3	Janus kinase 2, colony-stimulating factor 3 receptor	S13, S18	Inflammation, reactive oxygen species	Ruxolitinib, N-acetylcysteine

Citation: AlGarni A, Alanazi N, AlMukhaylid S, Alqahtani S, Almasoudi H, Samir Taleb Y, Alkhamis N, Shaheen S, Haji Siyal A, Aleem A, Naeem R, Shammas MA, Saglio G, Alroweilly D, Hussain A, Iqbal Z. Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing. World J Clin Oncol 2025; 16(11): 111983
URL: https://www.wjgnet.com/2218-4333/full/v16/i11/111983.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i11.111983

AlGarni A, Alanazi N, AlMukhaylid S, Alqahtani S, Almasoudi H, Samir Taleb Y, Alkhamis N, Shaheen S, Haji Siyal A, Aleem A, Naeem R, Shammas MA, Saglio G, Alroweilly D, Hussain A, Iqbal Z. Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing. World J Clin Oncol 2025; 16(11): 111983 [PMID: 41355924 DOI: 10.5306/wjco.v16.i11.111983]

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