ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role

Figure 1 Schematic representation of ADAM metallopeptidase with thrombospondin type 1 motif 8 and distribution in the human body under normal and cancer conditions[93]. The blue color represents healthy conditions, and the orange color represents tumor conditions. A higher intensity of color correlated with a higher expression of ADAM metallopeptidase with thrombospondin type 1 motif 8 (ADAMTS-8) in the indicated organ. A: Protein structure of ADAMTS-8; B: Schema modified of GEPIA web server based on expression of ADAMTS-8 in the human body. Citation: Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res 2017; 45: W98-W102. Copyright ©The Authors 2025. Published by Oxford University Press. (https://academic.oup.com/pages/open-research/open-access). ADAMTS-8: ADAM metallopeptidase with thrombospondin type 1 motif 8; TPM: Transcripts per million.