ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Nov 24, 2025; 16(11): 110202
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.110202

Table 2 Expression of KLK5 in some types of cancer

Cancer	*Expression of KLK5 in* the tumor compared with non-tumor conditions**	Ref.
Breast cancer	Expression depends on stage, grade, and metastasis	[65,66,70,74]
Oral squamous cell carcinoma	Expression depends on stage, grade, and metastasis	[88,89,97]
Vaginal carcinogenesis	Decreased	[34]
Prostate cancer	Decreased	[35]
Testicular cancer	Decreased	[67]
Ovarian cancer	Increased	[77,68]
Skin tumorigenesis	Increased	[61]
Urinary bladder carcinoma cells	Increased	[84]
Uterine cervical cancer	Increased	[76]
Lung cancer	Increased	[83]
Gastric adenocarcinoma	Increased	[81]

Citation: Palacios Serrato EG, Medina-Abreu KH, Oropeza-Martínez E, Jacinto-Alemán LF, Macías-Silva M, Tecalco-Cruz AC. ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role. World J Clin Oncol 2025; 16(11): 110202
URL: https://www.wjgnet.com/2218-4333/full/v16/i11/110202.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i11.110202

Palacios Serrato EG, Medina-Abreu KH, Oropeza-Martínez E, Jacinto-Alemán LF, Macías-Silva M, Tecalco-Cruz AC. ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role. World J Clin Oncol 2025; 16(11): 110202 [PMID: 41355923 DOI: 10.5306/wjco.v16.i11.110202]

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