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©The Author(s) 2025.
World J Clin Oncol. Nov 24, 2025; 16(11): 108667
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.108667
Figure 5
Figure 5 The evolution of chimeric antigen receptor structures through generational progression and next generation designs. A: Overview of the five generations of chimeric antigen receptor (CAR) structure; B: Prominent examples of some of the advanced CAR design approaches. ScFv: Single chain variable fragment; IFN-γ: Interferon-gamma; ARD: Antigen recognition domain; CAR: Chimeric antigen receptor.


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