©The Author(s) 2025.
World J Clin Oncol. Nov 24, 2025; 16(11): 108667
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.108667
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.108667
Figure 5 The evolution of chimeric antigen receptor structures through generational progression and next generation designs.
A: Overview of the five generations of chimeric antigen receptor (CAR) structure; B: Prominent examples of some of the advanced CAR design approaches. ScFv: Single chain variable fragment; IFN-γ: Interferon-gamma; ARD: Antigen recognition domain; CAR: Chimeric antigen receptor.
- Citation: Arjumand S, Raj A, Prattay KMR, Omer HBM, Azam F. Chimeric antigen receptor T cell therapy: Revolutionizing cancer treatment. World J Clin Oncol 2025; 16(11): 108667
- URL: https://www.wjgnet.com/2218-4333/full/v16/i11/108667.htm
- DOI: https://dx.doi.org/10.5306/wjco.v16.i11.108667