Neoadjuvant immunotherapy in resectable hepatocellular carcinoma: A meta-analysis of the current evidence

doi:10.5306/wjco.v16.i10.110511

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Clin Oncol. Oct 24, 2025; 16(10): 110511
Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110511

Table 3 Pooled event rates for clinical endpoints (%)

Endpoint	Pooled %	95%CI	I²	P value
MPR	19	13-25	0.0	0.77
ORR	35	18-52	84.1	< 0.001
pCR	22	10-34	85.5	< 0.001
Resection rate	81	72-91	75.9	< 0.001
Grade 3-4 TRAEs	19	11-26	34.2	0.16

Absolute pooled percentages with 95% confidence intervals for each endpoint (major pathological response, overall response rate, pathological complete response, resection rate, and grade 3-4 treatment-related adverse events), estimated using a random-effects model. 95%CI: 95% confidence interval; pCR: Pathological complete response; MPR: Major pathological response; ORR: Overall response rate; TRAE: Treatment-related adverse event.

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Citation: Cicerone O, Oliviero B, Mantovani S, Maiocchi L, Ravetta V, Berton F, Corallo S, Vanoli A, Maestri M. Neoadjuvant immunotherapy in resectable hepatocellular carcinoma: A meta-analysis of the current evidence. World J Clin Oncol 2025; 16(10): 110511
URL: https://www.wjgnet.com/2218-4333/full/v16/i10/110511.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i10.110511

Cicerone O, Oliviero B, Mantovani S, Maiocchi L, Ravetta V, Berton F, Corallo S, Vanoli A, Maestri M. Neoadjuvant immunotherapy in resectable hepatocellular carcinoma: A meta-analysis of the current evidence. World J Clin Oncol 2025; 16(10): 110511 [PMID: 41178932 DOI: 10.5306/wjco.v16.i10.110511]

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