Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma

Table 1 Clinicopathologic characteristics of upper tract urothelial carcinoma patients and human epidermal growth factor receptor 2 groups

Variable	Category	Total	HER2-negative	HER2-positive	P value
Age		66 (32-88)	68 (32-84)	65 (35-88)
Gender					0.736
	Male	93	51	42
	Female	52	27	25
Location					0.156
	Renal pelvis	78	44	34
	Ureter	64	34	30
	Both	3	0	3
pT stage					0.426
	≤ T1	36	16	20
	T2	31	18	13
	≥ T3	78	44	34
Grade					0.003
	Low	20	17	3
	High	125	61	64
Ki-67					0.479
	Low	30	14	16
	High	115	62	53
pN stage					0.646
	Yes	8	4	4
	No	137	74	63
Lymphovascular invasion					0.135
	pN1	39	17	22
	pN0	106	61	45
Laterality					0.639
	Left	68	30	38
	Right	77	31	46
Molecular subtypes					0.788
	Luminal	102	53	49
	Basal	22	14	8
	Double-positive	10	5	5
	Double-negative	11	6	5

HER2: Human epidermal growth factor receptor 2.