Immune pathway through endometriosis to ovarian cancer

Figure 4 Illustration of anti-CD47-based immunotherapy. CD47 is a glycoprotein that is very present in the tumor environment and exerts its inhibitory activity by binding to its counter-receptor, the signal regulatory protein-α (SIRPα), expressed in macrophages. It reduces phagocytosis by these, which culminates in the progression of the tumor microenvironment. It is highly expressed patients with endometriosis. A: CD47 binding to SIRPα inhibits phagocytosis; B: Anti-CD47 blocks the binding between CD47 and SIRPα, allowing phagocytosis to occur. Anti-CD47: Integrin-associated protein Antibody; CD47: Integrin-associated protein; MΦ: Macrophage; OC cells: Ovarian Cancer cells; SIRPα: signal regulatory protein alpha.