Targeting KRAS in pancreatic adenocarcinoma: Progress in demystifying the holy grail

doi:10.5306/wjco.v14.i8.285

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Aug 24, 2023 (publication date) through May 13, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Aug 24, 2023; 14(8): 285-296
Published online Aug 24, 2023. doi: 10.5306/wjco.v14.i8.285

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Figure 2 Kirsten rat sarcoma virus activation. Kirsten rat sarcoma virus is activated when guanine nucleotide exchange factor displaces guanosine diphosphate from nucleotide binding site allowing guanosine triphosphate (GTP) binding and inactivated upon GTP hydrolysis by intrinsic GTP-bound regulatory protein phosphatases (GTPase) activity enhanced by GTPase activating protein. GTP: Guanosine triphosphate; GAP: GTPase activating protein; GDP: Guanosine diphosphate; GEF: Guanine nucleotide exchange factor; KRAS: Kirsten rat sarcoma virus.

Citation: Elhariri A, Alhaj A, Ahn D, Sonbol MB, Bekaii-Saab T, Wu C, Rutenberg MS, Stauffer J, Starr J, Majeed U, Jones J, Borad M, Babiker H. Targeting KRAS in pancreatic adenocarcinoma: Progress in demystifying the holy grail. World J Clin Oncol 2023; 14(8): 285-296
URL: https://www.wjgnet.com/2218-4333/full/v14/i8/285.htm
DOI: https://dx.doi.org/10.5306/wjco.v14.i8.285