Classification of patients with metastatic colorectal cancer into consensus molecular subtypes into real-world: A pilot study

Table 3 Mutations identified in the n = 26 patients included in the final analysis through massive genomic sequencing using the TumorSec panel

Patient number	Mutation	Mutation variant classification	Affected protein	Variant type
1	TSC2	Missense	p.R1729C	SNV
	TP53	Missense	p.R175H	SNV
2	KRAS	Missense	p.G12C	SNV
3	KRAS	Missense	p.G12V	SNV
	TP53	Missense	p.R175H	SNV
4	KRAS	Missense	p.Q61H	SNV
	PIK3CA	Missense	p.E545G	SNV
5	TP53	Missense	p.P152L	SNV
6	KRAS	Missense	p.G12D	SNV
7	BRCA2	Missense	p.K584E	SNV
	ARID1A	Nonsense	p.Q1584	SNV
8	KRAS	Missense	p.N116H	SNV
	TP53	Missense	p.R175H	SNV
	PIK3CA	Missense	p.H1047R	SNV
	BRAF	Missense	p.N581Y	SNV
9	BRCA2	Frameshift (deletion)	p.N863Ifs11	SNV
	ARID1A	Frameshift (deletion)	p.P1326Rfs155	SNV
	PIK3CA	Missense	p.H1047R	SNV
10	PTEN	Nonsense	p.Y225	SNV
	KRAS	Missense	p.G12C	SNV
	TP53	Frameshift (insertion)	p.Q317Pfs20	SNV
11	KRAS	Missense	p.Q61H	SNV
12	KRAS	Missense	p.G12D	SNV
	TP53	Missense	p.R280K	SNV
13	TP53	Missense	p.R273H	SNV
14	KRAS	Missense	p.G12D	SNV
	TP53	Missense	p.P278L	SNV
15	KRAS	Missense	p.K117N	SNV
	TP53	Missense	p.R282W	SNV
16	KRAS	Missense	p.G12D	SNV
	TP53	Frameshift (deletion)	p.S260Qfs3	Deletion
17	KRAS	Missense	p.Q61L	SNV
	BRCA2	Missense	p.S3147Y	SNV
	TP53	Missense	p.R249G	SNV
18	KRAS	Missense	p.G12C	SNV
	ARID1A	Frameshift (deletion)	p.Q611Hfs7	Deletion
19	TP53	Missense	p.Y220C	SNV
20	KRAS	Missense	p.A59G	SNV
	KRAS	Missense	p.G12D	SNV
	TP53	Missense	p.H214R	SNV
21	NRAS	Missense	p.Q61R	SNV
	ARID1A	Frameshift (deletion)	p.K1072Nfs21	SNV
22	TP53	Missense	p.R273C	SNV
23	TP53	Nonsense	p.E51	SNV
	ARID1A	Frameshift (deletion)	p.Q372Sfs19	SNV
24	TP53	Missense	p.R248W	SNV
	PIK3CA	Missense	p.E545K	SNV
25	PTEN	Nonsense	p.Q149	SNV
	KRAS	Missense	p.G13D	SNV
	TSC2	Missense	p.R1713C	SNV
	TP53	Missense	p.R273C	SNV
	TP53	Missense	p.R158H	SNV
	ARID1A	Nonsense	p.R1335	SNV
26	BRCA2	Missense	p.E3002K	SNV
	TP53	Missense	p.C176Y	SNV

SNV: Single nucleotide variant.