Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer

doi:10.5306/wjco.v13.i8.712

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Aug 24, 2022; 13(8): 712-724
Published online Aug 24, 2022. doi: 10.5306/wjco.v13.i8.712

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Figure 1 Survival outcomes stratified by cytochrome P450 2D6 phenotype and by hormonal agent used. A: Kaplan-Meier curves showing 5-year recurrence-free survival stratified by cytochrome P450 2D6 phenotype (n = 70); B: Kaplan-Meier curves showing 5-year overall survival stratified by cytochrome P450 2D6 phenotype (n = 70); C: Kaplan-Meier curves showing 5-year recurrence-free survival stratified by hormonal agent received (n = 70); D: Kaplan-Meier curves showing 5-year overall survival stratified by hormonal agent received (n = 70). IM: Intermediate metabolizers; EM/UM: Extensive metabolizers/ultra metabolizers; AI: Aromatase inhibitors; HR: Hazard ratio; CI: Confidence interval.

Citation: Tan EY, Bharwani L, Chia YH, Soong RCT, Lee SSY, Chen JJC, Chan PMY. Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer. World J Clin Oncol 2022; 13(8): 712-724
URL: https://www.wjgnet.com/2218-4333/full/v13/i8/712.htm
DOI: https://dx.doi.org/10.5306/wjco.v13.i8.712