Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer

doi:10.5306/wjco.v13.i8.712

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Aug 24, 2022; 13(8): 712-724
Published online Aug 24, 2022. doi: 10.5306/wjco.v13.i8.712

Table 2 Details of cytochrome P450 2D6 genotyping for the 78 women classified into two phenotype groups: Intermediate metabolizers and extensive metabolizers/ultra metabolizers

Phenotype	CYP2D6 genotype	Number of women, n = 78
IM	10/10	25
	*10/41	2
	10/4	2
	10/5	3
	*10/EM/UM	20
	*5/EM/UM	5
EM/UM	EM/UM	21

IM: Intermediate metabolizers; EM/UM: Extensive metabolizers/ultra metabolizers; CYP2D6: Cytochrome P450 2D6.

Citation: Tan EY, Bharwani L, Chia YH, Soong RCT, Lee SSY, Chen JJC, Chan PMY. Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer. World J Clin Oncol 2022; 13(8): 712-724
URL: https://www.wjgnet.com/2218-4333/full/v13/i8/712.htm
DOI: https://dx.doi.org/10.5306/wjco.v13.i8.712