Retrospective Cohort Study
Copyright ©The Author(s) 2022.
World J Clin Oncol. Aug 24, 2022; 13(8): 688-701
Published online Aug 24, 2022. doi: 10.5306/wjco.v13.i8.688
Table 2 Comparison of pretransplant tumor characteristics, locoregional therapy, and posttransplant tumor characteristics between patients with mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma, matched 1:8 for pre- liver transplant factors and explant factors
Variable
Pre-LT factors
Explant factors
HCC-CC (n = 7)
HCC (n = 56)
P value
HCC (n = 56)
P value
Recipient characteristics
Age, mean ± SD58.0 ± 6.960.3 ± 9.20.31760.8 ± 7.10.2892
Male, n (%)4 (57.1)41 (73.2)0.3974 (57.1)0.3751
Etiology of liver disease, n (%)0.1920.7891
HCV6 (85.7)42 (75.0)41 (73.2)
Alcohol07 (12.5)3 (5.4)
HBV05 (8.9)5 (8.9)
NAFLD1 (14.3)03 (5.4)
Cryptogenic02 (3.6)4 (7.1)
CTP class, n (%)0.2010.5561
A3 (42.9)21 (37.5)29 (51.8)
B2 (28.6)30 (53.6)20 (35.7)
C2 (28.6)5 (8.9)7 (12.5)
Maximum pretransplant AFP, ng/mL 35.3(4.3-357.0)9.6(1.1-628.0)0.15016.5(1.1-6123.0)0.6683
Radiographic tumor characteristics
Cumulative tumor diameter, cm, n (%)0.2240.723t
< 2.11 (14.3)25 (44.6)11 (19.6)
2.2-5.04 (57.1)23 (41.1)36 (64.3)
5.12 (28.6)8 (14.3)9 (16.1)
Neoadjuvant therapy, n (%)0.0850.0811
None014 (25.0)12 (21.4)
TACE3 (42.9)22 (39.3)28 (50.0)
Other4 (57.1)20 (35.7)16 (28.6)
Pathologic tumor characteristics, n (%)
Total necrosis among treated patients, n/total n (%)3/7 (33.3)20/42 (47.6)0.800018/44 (40.1)0.2231
Within Milan criteria4 (57.1)39 (69.6)0.66935 (62.5)> 0.9991
Within UCSF criteria6 (85.7)49 (87.5)> 0.99945 (80.4)> 0.9991
Median cumulative nodule size0.2240.7231
< 2.11 (14.3)25 (44.6)11 (19.6)
2.2-5.04 (57.1)23 (41.1)36 (64.3)
> 5.12 (28.6)8 (14.3)9 (16.1)
Tumor grade, n/total n (%)0.7220.2331
101/36 (2.8)0
24/7 (57.1)24/36 (66.7)18/55 (32.7)
33/7 (42.9)11/36 (30.6)37/55 (67.3)
Microvascular invasion09 (16.1)0.58000