Co-relation of SARS-CoV-2 related 30-d mortality with HRCT score and RT-PCR Ct value-based viral load in patients with solid malignancy

Table 3 Univariate regression models of potential variables associated with 30 d all-cause mortality (n = 123)

	Odds ratio	P value
Age, yr
< 65	1
65-74	0.48 (0.13-1.78)	0.2756
≥ 75	1.42 (0.26-7.88)	0.6883
Sex
Male	1
Female	1.22 (0.51-2.96)	0.6567
Smoking status
Never smoked	1
Smoker (former/current)	5.54 (2.05-14.99)	0.0008
Unknown	2.19 (0.39-12.21)	0.3711
Obesity status
Not specified	1
Obese	0.69 (0.14-3.32)	0.6414
Number of comorbidities
0	1
1	2.67 (0.83-8.56)	0.0993
≥ 2	3.38 (1.12-10.20)	0.0303
Type of malignancy
Thorax	1
GIT	2.57 (0.19-34.48)	0.4758
HPB	4.5 (0.51-39.44)	0.1744
GUT	1.5 (0.16-13.75)	0.7198
Others	1.38 (0.11-17.67)	0.8022
Cancer status
Remission or no evidence of disease	1
Present, stable, or responding to treatment	1.02 (0.16-6.43)	0.9832
Present, progressive disease unknown	25.5 (5.14-126.59)	0.0001
Type of anticancer therapy
None in the 4 wk before COVID-19 diagnosis	1
Non-cytotoxic therapy targeted therapy/endocrine therapy	0.13 (0.01-1.28)	0.08
Immunotherapy	0	0.9981
Cytotoxic systemic therapy	0.19 (0.06-0.63)	0.0067
External beam radiotherapy	0.2 (0.02-2.18)	0.1867
Recent surgery
None in the 4 wk before COVID-19 diagnosis	1
Yes	0.41 (0.05-3.38)	0.4053
Baseline laboratory parameters
C reactive protein	1
D-dimer	4.44 (1.76-11.23)	0.0016
IL-6	18.48 (1.96-173.82)	0.0108
HRCT score
Mild	1
Moderate	3.44 (1.3-9.12)	0.0132
Severe	7.44 (1.58-35.1)	0.0112
RT-PCR Test (viral load)
Mild (49)	1
Moderate (30)	1.28 (0.40-4.14)	0.6786
High (44)	1.71 (0.62-4.76)	0.3933
Treatment of COVID-19
Hydroxychloroquine (HCQ) alone, azithromycin alone or with combination HCQ/azithromycin/ivermectin	1
+ Steroids	3.91 (0.39-39.31)
+ Remdesivir	31.06 (3.79-255.41)	0.2470
+ Tocilizumab		0.0014
+ Plasma therapy	75.25 (7.30-775.28)	0.0003
Presentation
Asymptomatic	1
Symptomatic	11.1 (1.43-85.85)	0.0211
Managed at
Home-based care	1
Ward admission	121.6 (21.8-677.7)	< 0.0001
ICU admission	0.4 (0.04-3.57)	0.4119

GIT: Gastrointestinal tract; HPB: Hepatopancreatobiliary; GUT: Genitourinary tract; COVID-19: Coronavirus disease 2019; ECOG: Eastern Cooperative Oncology Group; ICU: Intensive care unit.