Neoadjuvant treatment in non-small cell lung cancer: New perspectives with the incorporation of immunotherapy

Table 1 Clinical evidence for neoadjuvant immunotherapy in non-small cell lung cancer

Study	Phase	Stages	Treatment	Cycles	Patients included	Main endpoint	ORR	MPR	pCR
Forde et al[8]	I	I-IIIA	Nivolumab	2	21	Safety and feasibility	10%	45%	10%
LCMC3[14]	II	IB-IIIB	Atezolizumab	2	181	MPR	7%	20%	7%
NEOSTAR[18]	II	I-IIIA	Nivolumab vs nivolumab + ipilimumab1	3	44	MPR	22% vs 19%	24% vs 50%	10% vs 38%
Gao et al[15]	IB	IA-IIIB	Sintilimab	2	40	Safety	20%	40%	16%
NEOMUN[16]	II	II-IIIA	Pembrolizumab	2	15	Safety and feasibility	28%	27%	13%
IONESCO[17]	II	IB-IIIA	Durvalumab	3	46	% R0	8%	18%	7%
Shu et al[19]	II	IB-IIIA	Atezolizumab + carboplatin + nab-paclitaxel	4	30	MPR	63%	57%	33%
NADIM[20]	II	IIIA	Nivolumab + carboplatin + paclitaxel	3	46	PFS 24 mo	76%	83%	63%
SAK 16/14[21]	II	IIIA	Cisplatin + docetaxel followed by durvalumab2	2	62	DFS 12 mo	58%	60%	18%

¹Nivolumab x3 cycles with or without a single dose of ipilimumab.

²Cisplatin + docetaxel x3 cycles followed by 2 cycles of durvalumab. ORR: Objective response rate; MPR: Major pathological response; pCR: Pathological complete response; % R0: % complete resection; PFS 24 mo: Progression-free survival at 24 mo; DFS 12 mo: Disease-free survival at 12 mo.