Guidelines
Copyright ©The Author(s) 2022.
World J Clin Oncol. Apr 24, 2022; 13(4): 237-266
Published online Apr 24, 2022. doi: 10.5306/wjco.v13.i4.237
Table 5 Radiation therapy in patients with oligometastatic non-small cell lung cancer
Ref.
Type
Design
Palliative treatment
Histology
Presentation
No. of metastases/location
RT type
Follow-up (mo)
PFS (mo)
MFS (mo)
OS (mo)
Gomez et al[93], 2019Phase II RCT. MulticentreInduct. ChT: (RT + MT) vs MT49NSCLC (No EGFR, ALK)Synchronous. Metachronous≤ 3 (1%:65%)/lung, CNS, bone, liver SSRR, nodesSABR/SBRT (MTX) hypofra. RT (primary)38.814.2 (SABR/SBRT + MT) vs 4.4 (MT)11.9 (SABR/SBRT + MT) vs 5.741 (SABR/SBRT + MT) vs 17
Iyengar et al[95], 2018Phase II RCT. MulticentreInduct. ChT: (SBRT + mChT) vs mChT29NSCLC (No GFR, ALK)Synchronous≤ 5 (1%:21%, 2%-3%:76%)/lung, lymph, bone, SSRRSABR/SBRT (MTX) hypofra. RT (primary)9.619.7 (SABR/SBRT + MT) vs 3.5 (MT)NRNR (SABR/SBRT + MT) vs 17
Palma et al[94], 2020Phase II RCT. Multicentre(ChT + PT) vs (ChT + SABR/SBRT)99Lung (18/99)Synchronous. Metachronous≤ 5 (1%-3%:93%)/lung, bone, CNS, liver, SSRRSABR/SBRT5111.6 (SABR/SBRT + MT) vs 5.4 (TP-MT)NR50 (SABR/SBRT + MT) vs 22